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Aklief vs. Tretinoin

Aklief vs. Tretinoin

Are you looking for a way to treat acne that works? You’re not alone. With several options in the market today, comparing them and finding a product that best suits your needs can be difficult. This article makes it easy for you by comparing the top popular acne treatments today: Aklief and Tretinoin. 

Acne is a common problem that affects people of all ages. It can be caused by several factors, including genetics, hormones, and diet. One of the common methods for treating acne is through the use of topical treatments such as creams, gels, and lotions.

Keep reading for a detailed comparison of these two products, keep reading.

Aklief Acne Treatment

Aklief vs. Tretinoin

Aklief (trifarotene) is a prescription-only medication used to treat acne vulgaris in adults and children over the age of 9. It contains trifarotene 0.005% as an active ingredient. The medication is applied topically to the affected areas of the skin once daily, with one pump for the face and two pumps for the back, shoulders, chest, and other affected areas.

Dermatologist Dr. Julie Harper says that while many acne treatments address only face acne, Aklief treats acne on the face, shoulders, chest, and back.

Aklief works by targeting your skin’s oil glands to reduce sebum production. It reduces inflammation and helps prevent new blemishes from forming.

How to Use Aklief

Clean the affected area of your skin and pat dry with a towel before applying Aklief.

Apply a thin layer of Aklief to your face or other affected areas once a day in the evening. Avoid contacting your eyes, mouth, or mucous membranes because this could irritate you.

Moisturize your face every morning and evening with an oil-free lotion or cream that contains an SPF sunscreen rated 15 or higher (SPF 30 preferred).

You should continue treatment with Aklief until all signs of acne have cleared or as directed by your doctor.

You should continue treatment with Aklief until all signs of acne have cleared up completely or for as long as directed by your doctor.

How Aklief Works

Aklief treats acne by managing sebum production and reducing inflammation associated with acne. This prevents new breakouts and helps clear existing acne outbreaks so you can see clearer skin sooner.

Are you eager to know when you expect to see results? Aklief is effective; you can start seeing the results as early as two weeks after using it.


Aklief vs. Tretinoin

Tretinoin is a prescription medication used to treat acne. It helps to unclog pores and prevent new ones from forming.

Tretinoin (Retin-A) is a retinoid used to treat acne and improve the appearance of aging skin. It works by unclogging pores and reducing inflammation, which helps to clear up existing acne and prevent new blemishes from forming. It also helps reduce fine lines and wrinkles by stimulating collagen growth in the skin.

The common side effects include dryness, peeling, redness, burning, or stinging sensations.

How to Use Tretinoin

Wash and dry your face.

Moisturize your face and let it dry before applying Tretinoin.

Apply a pea-sized amount of cream or gel over the affected area once daily at bedtime to avoid interaction with the sunlight. Avoid the eye, nose area, and lips.

Wash your hands after applying Tretinoin.

How Does Tretinoin Work?

Tretinoin works by unplugging pores and reducing inflammation of the skin’s surface. It also helps to speed up cell turnover in the skin, which means dead cells shed more quickly and aren’t allowed to build up on your skin’s surface like acne breakouts.

Aklief vs. Tretinoin: A Detailed Comparison Between Aklief and Tretinoin

Aklief and Tretinoin are two of the most common retinoids used to treat acne. Both are effective against acne, but some differences determine which one suits your needs.

Tretinoin (or Retin-A) is a prescription medication that has been around for quite some time and is approved by the FDA for treating acne. It contains Tretinoin as its active ingredient.

One of the major differences between these two is the content of the active ingredient, Tretinoin. Aklief has 0.005%, while Tretinoin has a concentration ranging from 0.025%, to 0.05% to 0.1%. When starting the new treatment, the doctor will recommend you to begin with a low-concentrated one. Tretinoin has a higher concentration.

Aklief is a cream acne treatment, while Tretinoin is a cream and gel treatment.

Aklief is pricey compared to Tretinoin.

Aklief Pros and Cons


  • It’s easy to apply
  • It treats acne in the face, chest, shoulders, and back.
  • It’s used for children of age nine and above


  • It can make your skin to be sensitive to sunlight
  • Expensive
  • You cannot purchase it without a prescription

Tretinoin Pros and cons


  • Effective in treating acne, a common skin problem among teenagers and adults.
  • It’s easy to apply
  • It’s fairly affordable
  • Applied once


  • You may observe worse breakouts when beginning the treatment.
  • It may make your skin to be more sensitive to sunlight.


In the reviews, users are happy with the results of Aklief. More people with acne seem to be shifting from their previous treatment to Aklief. The most highlighted downside of this product is the price. However, users who have used it say it’s worth the price.

On the other hand, Retinoid also receives positive reviews from users for their effectiveness. However, users cannot distinguish between a purging phase and an indication that the product is not working.

What You Need to Know When Choosing a Retinoid

Choosing the right acne treatment can be difficult, especially between the two, since they are both effective in their ways. However, this comparison has made it simple to choose a product suitable for your skin type and other needs.

With the customer’s needs in mind, this comparison recommends Aklief treatment for those who want to treat acne and do not mind the price. Due to its mild side effects, it can be used by those nine years and older. Users on Reddit also seem to be shifting from other products to Aklief.

If you want an effective and affordable treatment, Tretinoin is for you. However, you need to consult with your doctor if it is the right one for your skin type, especially if you have sensitive skin. Your doctor may recommend Renin-A with a lower concentration of trifarotene.